Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777665 | 0.91 | IGF1R (0.53) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL12606272 | 0.87 | IGF1R (0.48) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1780095 | 0.87 | IGF1R (0.48) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1779372 | 0.87 | IGF1R (0.48) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL12606257 | 0.86 | IGF1R (0.58) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1777094 | 0.86 | IGF1R (0.48) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1779996 | 0.86 | IGF1R (0.48) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1778977 | 0.86 | IGF1R (0.48) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1778068 | 0.86 | IGF1R (0.48) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1778013 | 0.86 | MAPT (0.53) | IGF1RSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2233486-A1 | Azaindoles | Aventis Pharma Limited (GB) | 2010-09-29 | — | — | EP | disclosed |