Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA4 | P22748 | 3/20 | 0.36 |
| ▸ | CA7 | P43166 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15652000 | 0.85 | AKT1 (0.47) | AKT1HMOX1HRH4KCNH2MCHR1 | |
| SCHEMBL17076815 | 0.85 | AKT1 (0.47) | AKT1HMOX1HRH4KCNH2MCHR1 | |
| SCHEMBL1782143 | 0.84 | GRM2 (0.44) | AKT1HMOX1HRH4KCNH2MCHR1 | |
| SCHEMBL1782714 | 0.84 | GRM2 (0.44) | AKT1HMOX1HRH4KCNH2MCHR1 | |
| SCHEMBL1782278 | 0.84 | GRM2 (0.44) | AKT1HMOX1HRH4KCNH2MCHR1 | |
| SCHEMBL4885872 | 0.81 | HRH4 (0.49) | HRH4KCNH2MCHR1HRH3CA12 | |
| SCHEMBL18391586 | 0.79 | PDE10A (0.39) | ACACB | |
| SCHEMBL13349205 | 0.79 | AKT1 (0.49) | AKT1HMOX1HRH4KCNH2ROCK2 | |
| SCHEMBL4780968 | 0.77 | CA12 (0.49) | KCNH2MCHR1CA12CA1CA2 | |
| SCHEMBL14196277 | 0.77 | PDE10A (0.48) | KCNH2MCHR1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118261-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | GLAXO GROUP LIMITED | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118261-A1 | BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS | MCHR1, MCHR2, MC1R | AKT1 4636/4885HMOX1 421/4885HRH4 342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.