Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 8/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17785736 | 0.81 | USP30 (0.46) | USP30RETCNR1CNR2LRRK2 | |
| SCHEMBL29471152 | 0.79 | USP30 (0.41) | USP30RETCNR1CNR2PIK3CD | |
| SCHEMBL17799507 | 0.79 | USP30 (0.41) | USP30RETCNR1CNR2PIK3CD | |
| SCHEMBL31601615 | 0.79 | USP30 (0.45) | USP30RETCNR1CNR2LRRK2 | |
| SCHEMBL17809788 | 0.78 | USP30 (0.51) | USP30CNR1CNR2PIK3CDFGFR3 | |
| SCHEMBL17809794 | 0.78 | USP30 (0.51) | USP30CNR1CNR2PIK3CDFGFR3 | |
| SCHEMBL17809580 | 0.78 | USP30 (0.51) | USP30CNR1CNR2PIK3CDFGFR3 | |
| SCHEMBL17806328 | 0.74 | USP30 (0.48) | USP30RETCNR1CNR2PIK3CD | |
| SCHEMBL17806392 | 0.74 | USP30 (0.48) | USP30RETCNR1CNR2PIK3CD | |
| SCHEMBL17806364 | 0.74 | USP30 (0.48) | USP30RETCNR1CNR2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086200-A9 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016086200-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-02 | — | — | WO | disclosed |