Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.39 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.39 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 11/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17795599 | 0.89 | USP30 (0.39) | USP30SRPK2SRPK1EML4ALK | |
| SCHEMBL17809692 | 0.79 | USP30 (0.42) | USP30RETCNR1CNR2LRRK2 | |
| SCHEMBL21254931 | 0.78 | USP30 (0.39) | USP30RETCNR1CNR2LRRK2 | |
| SCHEMBL19175599 | 0.76 | LRRK2 (0.43) | USP30RETCNR1CNR2LRRK2 | |
| SCHEMBL19663510 | 0.75 | USP30 (0.40) | USP30RETCNR1CNR2LRRK2 | |
| SCHEMBL19628541 | 0.75 | USP30 (0.42) | USP30SRPK2SRPK1EML4ALK | |
| SCHEMBL2661102 | 0.73 | PIK3CD (0.39) | USP30RETCNR1CNR2LRRK2 | |
| SCHEMBL17794955 | 0.72 | LRRK2 (0.48) | USP30RETCNR1CNR2LRRK2 | |
| SCHEMBL17809747 | 0.71 | USP30 (0.50) | USP30RETCNR1CNR2LRRK2 | |
| SCHEMBL19175137 | 0.71 | ERN1 (0.44) | USP30RETCNR1CNR2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086200-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-02 | — | — | WO | disclosed |