Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17797642 | 0.91 | TMPRSS2 (0.53) | TMPRSS2NPC1RAB9AABCB1HSD17B3 | |
| SCHEMBL17797522 | 0.86 | ESR2 (0.56) | TMPRSS2NPC1RAB9AABCB1ABCC1 | |
| SCHEMBL11295872 | 0.80 | ESR1 (0.71) | TMPRSS2NPC1RAB9AABCB1ABCC1 | |
| SCHEMBL20536418 | 0.80 | HSD17B3 (0.57) | TMPRSS2NPC1RAB9AHSD17B3TAAR1 | |
| SCHEMBL17797500 | 0.80 | MAPT (0.49) | NPC1RAB9ASMN1; SMN2HIF1AMAPT | |
| SCHEMBL2639196 | 0.79 | HSD17B3 (0.68) | TMPRSS2NPC1RAB9AHSD17B3SMN1; SMN2 | |
| SCHEMBL31005784 | 0.79 | MAPT (0.53) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL17797492 | 0.79 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL1950717 | 0.78 | KMT2A (0.49) | TMPRSS2RAB9AHSD17B3HPGDTAAR1 | |
| SCHEMBL14871708 | 0.78 | KDM4E (0.62) | TMPRSS2NPC1RAB9AHSD17B3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159774-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE CAR LLC (BM) | 2016-06-09 | — | — | US | disclosed |
| WO-2016090079-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159774-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | TMPRSS2 1614/4885NPC1 48/4885RAB9A 580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.