Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.55 |
| ▸ | PIM1 | P11309 | 4/20 | 0.55 |
| ▸ | GSK3B | P49841 | 4/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459163 | 0.96 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| Trifluoroacetic Acid SCHEMBL1780688 | 0.89 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| Trifluoroacetic Acid SCHEMBL1780024 | 0.88 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| Trifluoroacetic Acid SCHEMBL1780785 | 0.88 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| Trifluoroacetic Acid SCHEMBL1782047 | 0.88 | PIK3CD (0.56) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| Trifluoroacetic Acid SCHEMBL1780122 | 0.87 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| Trifluoroacetic Acid SCHEMBL1779645 | 0.87 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| Trifluoroacetic Acid SCHEMBL1781802 | 0.86 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL1251729 | 0.85 | PIK3CD (0.63) | PIK3CDPIK3CBPIK3CGPIM1GSK3B | |
| SCHEMBL1779554 | 0.85 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGPIM1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765743-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-01 | — | — | US | disclosed |
| US-20110118246-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118246-A1 | Novel Compounds | PIK3CA, PIK3C2B, PIK3CD | PIK3CD 3/4885PIK3CB 4/4885PIK3CG 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.