Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.46 |
| ▸ | WNT1 | P04628 | 5/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801012 | 0.91 | MAP3K5 (0.54) | MAP3K5CSNK1DLRRK2DYRK1AWNT1 | |
| SCHEMBL17801074 | 0.89 | MAP3K5 (0.55) | MAP3K5CSNK1DLRRK2DYRK1AWNT1 | |
| SCHEMBL5388782 | 0.87 | MAP3K5 (0.62) | MAP3K5CSNK1DLRRK2DYRK1AWNT1 | |
| SCHEMBL5389216 | 0.83 | MAP3K5 (0.58) | MAP3K5CSNK1DDYRK1AWNT1 | |
| SCHEMBL8257307 | 0.79 | MAP3K5 (0.61) | MAP3K5LRRK2DYRK1AWNT1MAPK8 | |
| SCHEMBL17801033 | 0.79 | MAP3K5 (0.55) | MAP3K5CSNK1DLRRK2DYRK1AWNT1 | |
| SCHEMBL17801053 | 0.79 | MAP3K5 (0.55) | MAP3K5CSNK1DLRRK2DYRK1AWNT1 | |
| SCHEMBL5378042 | 0.77 | MAP3K5 (0.59) | MAP3K5LRRK2DYRK1AWNT1MAPK8 | |
| SCHEMBL8365710 | 0.76 | MAP3K5 (0.57) | MAP3K5CSNK1DLRRK2DYRK1AWNT1 | |
| SCHEMBL8258727 | 0.76 | MAP3K5 (0.57) | MAP3K5LRRK2DYRK1AWNT1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | claimed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |