Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.46 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378093 | 0.86 | CSNK1D (0.69) | CSNK1DTRPA1ITKAOC3MAP2K4 | |
| SCHEMBL17801058 | 0.82 | CSNK1D (0.76) | CSNK1DLRRK2ITKMAPK1 | |
| SCHEMBL5377874 | 0.76 | CSNK1D (0.67) | CSNK1DITKMAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL17801018 | 0.73 | CSNK1D (0.50) | CSNK1DTRPA1SCN5ASCN9ALRRK2 | |
| SCHEMBL1664137 | 0.73 | LRRK2 (0.58) | TRPA1SCN5ASCN9ALRRK2ITK | |
| SCHEMBL2857828 | 0.73 | LRRK2 (0.54) | CSNK1DTRPA1SCN5ASCN9ALRRK2 | |
| SCHEMBL17801056 | 0.72 | TLR9 (0.50) | CSNK1DTRPA1SCN5ASCN9ALRRK2 | |
| SCHEMBL5373431 | 0.72 | CSNK1D (0.68) | CSNK1DITKMAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL5372371 | 0.71 | CSNK1D (0.64) | CSNK1DLRRK2ITKMAP2K4MAPK1 | |
| SCHEMBL17801074 | 0.71 | MAP3K5 (0.55) | CSNK1DLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | claimed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |