Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 8/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.54 |
| ▸ | MAPKAPK3 | Q16644 | 3/20 | 0.54 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4176018 | 0.80 | MAP2K4 (0.47) | MAP2K4MAPK1MAPK6MAPKAPK3MAP3K5 | |
| SCHEMBL8365710 | 0.73 | MAP3K5 (0.57) | MAP3K5MAPK8CSNK1DMAPK10MAPK14 | |
| SCHEMBL8260308 | 0.73 | CSNK1D (0.63) | MAP2K4MAPK1MAPK6MAPKAPK3MAP3K5 | |
| SCHEMBL8254855 | 0.72 | MAP3K5 (0.57) | MAP3K5MAPK8CSNK1DMAPK10MAPK14 | |
| SCHEMBL5372266 | 0.72 | MAP2K4 (0.63) | MAP2K4MAPK1MAPK6MAPKAPK3MAP3K5 | |
| SCHEMBL5817740 | 0.72 | CSNK1D (0.46) | MAP2K4MAPK1MAPK6MAPKAPK3MAPK8 | |
| SCHEMBL2860093 | 0.72 | MAP2K4 (0.71) | MAP2K4MAPK1MAPK6MAPKAPK3MAP3K5 | |
| SCHEMBL22801827 | 0.71 | MAP2K4 (1.00) | MAP2K4MAPK1MAPK6MAPKAPK3MAPK8 | |
| SCHEMBL8252483 | 0.71 | CSNK1D (0.75) | MAP2K4MAP3K5MAPK8CSNK1DMAPK10 | |
| SCHEMBL8252492 | 0.71 | MAP3K5 (0.53) | MAP3K5CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |