Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 7/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17804357 | 0.84 | EZH2 (0.38) | EZH2ALDH1A1NPC1KDM4E | |
| SCHEMBL18829944 | 0.83 | EZH2 (0.41) | EZH2OPRK1ALDH1A1GAAMAPT | |
| SCHEMBL13277322 | 0.81 | EZH2 (0.54) | EZH2OPRK1 | |
| SCHEMBL18829978 | 0.81 | EZH2 (0.40) | EZH2OPRK1ALDH1A1GAAMAPT | |
| SCHEMBL13280720 | 0.81 | EZH2 (0.40) | EZH2OPRK1ALDH1A1NPSR1NPC1 | |
| SCHEMBL30687996 | 0.80 | EZH2 (0.53) | EZH2OPRK1 | |
| SCHEMBL13276867 | 0.80 | EZH2 (0.53) | EZH2OPRK1 | |
| SCHEMBL13280289 | 0.80 | MEN1 (0.41) | EZH2OPRK1ALDH1A1GAAMAPT | |
| SCHEMBL15710441 | 0.80 | MEN1 (0.40) | EZH2OPRK1ALDH1A1NPC1KDM4E | |
| SCHEMBL15709875 | 0.79 | CFTR (0.40) | EZH2OPRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697198-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2016-06-08 | — | — | EP | disclosed |