Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.86 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13276799 | 0.92 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL13277885 | 0.91 | EZH2 (0.89) | EZH2HDAC1HDAC6 | |
| SCHEMBL13277359 | 0.90 | EZH2 (0.86) | EZH2HDAC1HDAC6 | |
| SCHEMBL13277247 | 0.89 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL13277721 | 0.89 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL14806637 | 0.88 | EZH2 (0.84) | EZH2HDAC1HDAC6 | |
| SCHEMBL15700591 | 0.87 | EZH2 (0.95) | EZH2HDAC1HDAC6 | |
| SCHEMBL15648844 | 0.86 | EZH2 (0.88) | EZH2HDAC1HDAC6 | |
| SCHEMBL22561600 | 0.86 | EZH2 (0.88) | EZH2HDAC1HDAC6 | |
| SCHEMBL15648843 | 0.86 | EZH2 (0.88) | EZH2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697199-B1 | ARYL-OR HETEROARYL-SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2016-06-08 | — | — | EP | disclosed |