Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 4/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18440828 | 1.00 | KMT2A (0.48) | KMT2ACA1CA2CA4MT-CO2 | |
| SCHEMBL21027179 | 0.98 | — | — | |
| SCHEMBL87331 | 0.90 | — | — | |
| SCHEMBL62747 | 0.90 | — | — | |
| SCHEMBL24943786 | 0.86 | CA1 (0.37) | KMT2ACA1CA2CA4MT-CO2 | |
| SCHEMBL3397908 | 0.83 | KMT2A (0.50) | KMT2ACA1CA2CA4MT-CO2 | |
| SCHEMBL3721835 | 0.83 | KMT2A (0.50) | KMT2ACA1CA2CA4MT-CO2 | |
| SCHEMBL3477839 | 0.83 | KMT2A (0.50) | KMT2ACA1CA2CA4MT-CO2 | |
| SCHEMBL7706359 | 0.83 | KMT2A (0.50) | KMT2ACA1CA2CA4MT-CO2 | |
| SCHEMBL7109157 | 0.83 | KMT2A (0.50) | KMT2ACA1CA2CA4MT-CO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301927-B1 | Cyclopropanated macrocyclic lactone | INT FLAVORS & FRAGRANCES INC (US) | 2016-01-27 | — | — | EP | disclosed |
| EP-1712538-B1 | Cyclopropanated macrocyclic ketone | INT FLAVORS & FRAGRANCES INC (US) | 2011-07-27 | — | — | EP | disclosed |
| US-7943559-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943559-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943559-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943560-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943560-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943560-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2301927-A1 | Cyclopropanated macrocyclic lactone | International Flavors & Fragrances Inc. (US) | 2011-03-30 | — | — | EP | disclosed |
| US-20090087402-A1 | Cyclopropanated Macrocyclic Ketones and Lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2009-04-02 | — | — | US | disclosed |
| US-7485668-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-7485668-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-7482380-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482380-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482380-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20070142253-A1 | Cyclopropanated Macrocyclic Ketones and Lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2007-06-21 | — | — | US | disclosed |
| US-20070142253-A1 | Cyclopropanated Macrocyclic Ketones and Lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2007-06-21 | — | — | US | disclosed |
| US-20070142253-A1 | Cyclopropanated Macrocyclic Ketones and Lactones | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2007-06-21 | — | — | US | disclosed |
| US-7189881-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189881-B2 | Cyclopropanated macrocyclic ketones and lactones | INTERNATIONAL FLAVORS & FRAGRANCES, INC. (US) | 2007-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142253-A1 | Cyclopropanated Macrocyclic Ketones and Lactones | CBR3, CBR1, DCXR | KMT2A 2816/4885CA1 2906/4885CA2 2803/4885 |
| US-20090087402-A1 | Cyclopropanated Macrocyclic Ketones and Lactones | CBR3, CBR1, DCXR | KMT2A 2512/4885CA1 2934/4885CA2 2754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.