Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.46 |
| ▸ | IL2 | P60568 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17805352 | 0.90 | STIM1 (0.41) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12241382 | 0.89 | STIM1 (0.50) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12155913 | 0.81 | IL2 (0.53) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12241379 | 0.81 | STIM1 (0.66) | STIM1ORAI1ORAI2IL2L3MBTL1 | |
| SCHEMBL16572570 | 0.78 | STIM1 (0.54) | STIM1ORAI1ORAI2IL2RAB9A | |
| SCHEMBL12241380 | 0.77 | SMN1; SMN2 (0.47) | STIM1ORAI1IL2ALDH1A1SMN1; SMN2 | |
| SCHEMBL12155685 | 0.75 | SMN1; SMN2 (0.51) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL1702092 | 0.75 | STIM1 (0.67) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12155682 | 0.74 | STIM1 (0.52) | STIM1ORAI1ORAI2IL2ALDH1A1 | |
| SCHEMBL12241882 | 0.74 | STIM1 (0.51) | STIM1ORAI1ORAI2IL2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563776-B1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC (US) | 2016-06-08 | — | — | EP | disclosed |