Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13311138 | 0.90 | HRH4 (0.37) | HRH4POLBRAB9AMEN1KMT2A | |
| SCHEMBL17805755 | 0.88 | HRH4 (0.35) | HRH4POLBRAB9AMEN1KMT2A | |
| SCHEMBL13311142 | 0.84 | KDR (0.43) | MEN1KMT2ANPC1RXFP1MAPT | |
| SCHEMBL13343605 | 0.83 | HRH4 (0.37) | HRH4POLBRAB9AHRH3 | |
| SCHEMBL10080014 | 0.76 | HRH4 (0.36) | HRH4POLBRAB9AMEN1KMT2A | |
| SCHEMBL6518352 | 0.76 | KDR (0.55) | MEN1KMT2AMAPTHTT | |
| SCHEMBL13311133 | 0.76 | HRH4 (0.36) | HRH4POLBRAB9AMEN1KMT2A | |
| SCHEMBL14138287 | 0.73 | HRH4 (0.42) | HRH4POLBRAB9AMEN1KMT2A | |
| SCHEMBL13805703 | 0.73 | HRH4 (0.33) | HRH4POLBRAB9AMEN1KMT2A | |
| SCHEMBL13311120 | 0.72 | HRH4 (0.51) | HRH4MEN1KMT2ANPC1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121667-B1 | CHEMICAL LINKERS WITH SINGLE AMINO ACIDS AND CONJUGATES THEREOF | SQUIBB & SONS LLC (US) | 2016-06-08 | — | — | EP | disclosed |