Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 20/20 | 0.80 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.80 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.80 |
| ▸ | NQO2 | P16083 | 1/20 | 0.80 |
| ▸ | SMC2 | O95347 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.68 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.68 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.68 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.68 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.68 |
| ▸ | BRAF | P15056 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17806506 | 0.92 | MAP2K1 (0.81) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| SCHEMBL29990127 | 0.90 | MAP2K1 (0.88) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| SCHEMBL25189605 | 0.90 | MAP2K1 (0.88) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| SCHEMBL25480020 | 0.89 | MAP2K1 (0.84) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| SCHEMBL15704258 | 0.89 | MAP2K1 (0.84) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| Binimetinib SCHEMBL570088 | 0.89 | MAP2K1 (1.00) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| Binimetinib SCHEMBL29363187 | 0.89 | MAP2K1 (1.00) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| SCHEMBL29199685 | 0.89 | MAP2K1 (0.83) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| SCHEMBL15647087 | 0.88 | MAP2K1 (0.81) | MAP2K1MAP2K2ABCB11NQO2SMC2 | |
| SCHEMBL29992273 | 0.88 | MAP2K1 (0.81) | MAP2K1MAP2K2ABCB11NQO2SMC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089208-A2 | SULFONAMIDE, SULFAMATE AND SULFAMIDE DERIVATIVES OF ANTI-CANCER AGENTS | STICHTING MAASTRICHT RADIATION ONCOLOGY "MAASTRO-CLINIC" (NL) | 2016-06-09 | — | — | WO | disclosed |