Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.38 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17806745 | 0.83 | CYP2C19 (0.39) | CYP2C19CYP3A4PRKDCBRD4ALDH1A1 | |
| SCHEMBL17794789 | 0.78 | CYP2C19 (0.46) | CYP2C19CYP3A4BRD4ALDH1A1L3MBTL1 | |
| SCHEMBL17809689 | 0.77 | CYP2C19 (0.45) | CYP2C19CYP3A4PRKDCBRD4ALDH1A1 | |
| SCHEMBL17795432 | 0.75 | PRMT5 (0.47) | CYP2C19CYP3A4BRD4ALDH1A1L3MBTL1 | |
| SCHEMBL21051429 | 0.72 | BRD4 (0.45) | CYP2C19CYP3A4BRD4ALDH1A1L3MBTL1 | |
| SCHEMBL17785580 | 0.72 | BRD4 (0.45) | CYP2C19CYP3A4BRD4ALDH1A1L3MBTL1 | |
| SCHEMBL17806490 | 0.71 | BRD4 (0.42) | CYP2C19CYP3A4BRD4ALDH1A1L3MBTL1 | |
| SCHEMBL17809695 | 0.71 | BRD4 (0.43) | CYP2C19CYP3A4BRD4ALDH1A1L3MBTL1 | |
| SCHEMBL16479495 | 0.69 | S1PR2 (0.45) | CYP2C19CYP3A4PRKDCBRD4ALDH1A1 | |
| SCHEMBL3329152 | 0.69 | CYP2C19 (0.43) | CYP2C19CYP3A4BRD4ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | CYP2C19 3069/4885CYP3A4 3799/4885PRKDC 2793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.