Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.68 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3719586 | 0.99 | SIRT2 (0.67) | SIRT2SIRT1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL17811405 | 0.90 | SIRT2 (0.69) | SIRT2SIRT1ALDH1A1MAPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL3719590 | 0.89 | SIRT2 (0.68) | SIRT2SIRT1ALDH1A1MAPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL3721503 | 0.89 | SIRT2 (0.64) | SIRT2SIRT1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16229470 | 0.86 | SIRT2 (0.85) | SIRT2SIRT1ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3725394 | 0.83 | SIRT2 (0.61) | SIRT2SIRT1ALDH1A1MAPTGAA | |
| Hydrochloric Acid SCHEMBL1706649 | 0.81 | SIRT2 (0.98) | SIRT2SIRT1 | |
| SCHEMBL16229460 | 0.80 | SIRT2 (0.82) | SIRT2SIRT1ALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL3721508 | 0.79 | SIRT2 (0.66) | SIRT2SIRT1ALDH1A1MAPTCYP1A2 | |
| SCHEMBL1458450 | 0.78 | MEN1 (0.62) | SIRT2SIRT1ALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365508-B2 | Aroyl thiourea derivatives | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2016-06-14 | — | — | US | claimed |