Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 20/20 | 0.61 |
| ▸ | HCRTR1 | O43613 | 18/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17803665 | 0.89 | HCRTR1 (0.61) | HCRTR2HCRTR1CYP3A4 | |
| SCHEMBL17812932 | 0.89 | HCRTR1 (0.61) | HCRTR2HCRTR1CYP3A4 | |
| SCHEMBL7918180 | 0.84 | HCRTR2 (0.65) | HCRTR2HCRTR1 | |
| SCHEMBL7915973 | 0.84 | HCRTR2 (0.65) | HCRTR2HCRTR1 | |
| SCHEMBL2291824 | 0.84 | HCRTR2 (0.65) | HCRTR2HCRTR1 | |
| SCHEMBL17812933 | 0.82 | HCRTR2 (0.51) | HCRTR2HCRTR1CYP3A4 | |
| SCHEMBL17812927 | 0.82 | HCRTR2 (0.51) | HCRTR2HCRTR1CYP3A4 | |
| SCHEMBL17803651 | 0.81 | HCRTR2 (0.48) | HCRTR2HCRTR1 | |
| SCHEMBL19564500 | 0.81 | HCRTR2 (0.51) | HCRTR2HCRTR1CYP3A4 | |
| SCHEMBL17812946 | 0.81 | HCRTR2 (0.59) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086358-A1 | HYDROXYMETHYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-06-09 | — | — | WO | disclosed |