Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.62 |
| ▸ | BTK | Q06187 | 5/20 | 0.62 |
| ▸ | ITK | Q08881 | 5/20 | 0.62 |
| ▸ | JAK3 | P52333 | 5/20 | 0.57 |
| ▸ | BMX | P51813 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17813212 | 0.85 | EGFR (0.65) | EGFRBTKITKJAK3BMX | |
| SCHEMBL17797488 | 0.85 | EGFR (0.65) | EGFRBTKITKJAK3BMX | |
| SCHEMBL17797487 | 0.85 | EGFR (0.65) | EGFRBTKITKJAK3BMX | |
| SCHEMBL18165629 | 0.77 | EGFR (1.00) | EGFRBTKITKJAK3BMX | |
| SCHEMBL29722531 | 0.77 | EGFR (1.00) | EGFRBTKITKJAK3BMX | |
| SCHEMBL29722324 | 0.77 | EGFR (1.00) | EGFRBTKITKJAK3BMX | |
| SCHEMBL21443638 | 0.77 | EGFR (1.00) | EGFRBTKITKJAK3BMX | |
| SCHEMBL12519541 | 0.77 | EGFR (1.00) | EGFRBTKITKJAK3BMX | |
| SCHEMBL12519532 | 0.77 | EGFR (1.00) | EGFRBTKITKJAK3BMX | |
| SCHEMBL24486516 | 0.77 | EGFR (0.83) | EGFRBTKITKJAK3BMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016090079-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |