Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17797537 | 0.96 | TMEM97 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14429561 | 0.85 | HRH3 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL30981352 | 0.85 | NPC1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17797663 | 0.83 | TMEM97 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9447608 | 0.82 | NPC1 (0.65) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17797709 | 0.81 | KMT2A (0.46) | NPC1RAB9AALDH1A1TP53MAPT | |
| SCHEMBL17797565 | 0.80 | TMEM97 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6296040 | 0.80 | TMPRSS2 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL30981397 | 0.80 | TMEM97 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6292442 | 0.79 | TMEM97 (0.62) | HRH3TMEM97SIGMAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016090079-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |