SCHEMBL17813631

SCHEMBL17813631

O[C@@H](CCc1cccc(-c2noc3ncccc23)c1)CN1CCc2ccccc2C1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 0.50
WDR77 Q9BQA1 18/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5359554 0.84 PRMT5 (0.67) PRMT5WDR77
SCHEMBL1383760 0.84 PRMT5 (0.67) PRMT5WDR77
SCHEMBL5359535 0.73 PRMT5 (0.52) PRMT5WDR77
SCHEMBL5359523 0.73 PRMT5 (0.52) PRMT5WDR77
SCHEMBL17947767 0.73 PRMT5 (0.73) PRMT5WDR77
SCHEMBL19163894 0.69 PRMT5 (0.47) PRMT5WDR77
SCHEMBL5368418 0.67 KDM4E (0.60) PRMT5WDR77
SCHEMBL1385362 0.67 KDM4E (0.60) PRMT5WDR77
SCHEMBL15944174 0.67 PRMT5 (1.00) PRMT5WDR77
SCHEMBL30019323 0.66 CARM1 (0.74) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016089883-A1 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF PROSTATE CANCER NOVARTIS AG (CH) 2016-06-09 WO disclosed