Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19741772 | 0.88 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19741951 | 0.84 | IDH1 (1.00) | IDH1 | |
| SCHEMBL17814273 | 0.84 | IDH1 (0.76) | IDH1 | |
| SCHEMBL17814461 | 0.82 | IDH1 (0.74) | IDH1 | |
| SCHEMBL17814569 | 0.81 | IDH1 (0.76) | IDH1 | |
| SCHEMBL17814509 | 0.81 | IDH1 (0.77) | IDH1 | |
| SCHEMBL17814446 | 0.81 | IDH1 (0.78) | IDH1 | |
| SCHEMBL17814068 | 0.80 | IDH1 (0.75) | IDH1 | |
| SCHEMBL17814398 | 0.80 | IDH1 (1.00) | IDH1 | |
| SCHEMBL19742016 | 0.80 | IDH1 (1.00) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089797-A1 | NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES | MERCK SHARP & DOHME CORP. (US) | 2016-06-09 | — | — | WO | disclosed |