Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 13/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29875150 | 0.82 | S1PR1 (0.40) | S1PR1S1PR5S1PR3FAAH | |
| SCHEMBL17815751 | 0.82 | S1PR1 (0.40) | S1PR1S1PR5S1PR3FAAH | |
| SCHEMBL29874504 | 0.78 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL19583402 | 0.78 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL19600981 | 0.78 | S1PR1 (0.63) | S1PR1S1PR3 | |
| SCHEMBL17815750 | 0.77 | S1PR1 (0.64) | S1PR1S1PR3 | |
| SCHEMBL29874910 | 0.77 | S1PR1 (0.64) | S1PR1S1PR3 | |
| SCHEMBL21296210 | 0.77 | MAOB (0.48) | S1PR1S1PR5S1PR3 | |
| SCHEMBL19583403 | 0.77 | S1PR5 (0.45) | MCHR1S1PR1S1PR5S1PR3 | |
| SCHEMBL16290137 | 0.76 | S1PR1 (0.67) | S1PR1S1PR5S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11471436-B2 | Dihydronaphthalene derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-10-18 | — | — | US | claimed |
| EP-3228615-B1 | DIHYDRONAPHTHALENE DERIVATIVES USEFUL IN THE TREATMENT OF S1P5-MEDIATED DISEASES | ONO PHARMACEUTICAL CO (JP) | 2021-01-20 | — | — | EP | claimed |
| US-20170327439-A1 | DIHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-11-16 | — | — | US | claimed |
| EP-3228615-A1 | DIHYDRONAPHTHALENE DERIVATIVE | ONO Pharmaceutical Co., Ltd. (JP) | 2017-10-11 | — | — | EP | claimed |
| US-11471436-B2 | Dihydronaphthalene derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-10-18 | — | — | US | disclosed |
| EP-3228615-B1 | DIHYDRONAPHTHALENE DERIVATIVES USEFUL IN THE TREATMENT OF S1P5-MEDIATED DISEASES | ONO PHARMACEUTICAL CO (JP) | 2021-01-20 | — | — | EP | disclosed |
| US-20170327439-A1 | DIHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-11-16 | — | — | US | disclosed |
| US-20170327439-A1 | DIHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-11-16 | — | — | US | disclosed |
| US-20170327439-A1 | DIHYDRONAPHTHALENE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2017-11-16 | — | — | US | disclosed |
| EP-3228615-A1 | DIHYDRONAPHTHALENE DERIVATIVE | ONO Pharmaceutical Co., Ltd. (JP) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016088834-A1 | DIHYDRONAPHTHALENE DERIVATIVE | 小野薬品工業株式会社 | 2016-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327439-A1 | DIHYDRONAPHTHALENE DERIVATIVE | S1PR5, LPAR5, S1PR1 | MCHR1 532/4885S1PR1 3/4885S1PR5 1/4885 |
| US-11471436-B2 | Dihydronaphthalene derivative | S1PR5, LPAR5, S1PR1 | MCHR1 433/4885S1PR1 3/4885S1PR5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.