⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13831267 | 0.82 | — | — | |
| SCHEMBL24797485 | 0.79 | ESR1 (0.31) | — | |
| SCHEMBL14730450 | 0.79 | ESR1 (0.31) | — | |
| SCHEMBL8950600 | 0.76 | ESR1 (0.34) | — | |
| SCHEMBL22856445 | 0.76 | ESR1 (0.34) | — | |
| SCHEMBL31563692 | 0.76 | ESR1 (0.34) | — | |
| SCHEMBL3042982 | 0.72 | — | — | |
| SCHEMBL16039913 | 0.72 | — | — | |
| SCHEMBL16037580 | 0.72 | — | — | |
| SCHEMBL19645308 | 0.71 | EPHX2 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026107328-A1 | AGONISTS OF PARATHYROID HORMONE 1 AND INCRETIN RECEPTORS | SEPTERNA, INC. (US) | 2026-05-21 | — | — | WO | disclosed |
| CN-107001295-B | Isoxazole hydroxamic acid compounds as LpxC inhibitors | 诺华股份有限公司 | 2021-02-02 | — | — | CN | disclosed |
| EP-3233843-B1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LPXC INHIBITORS | NOVARTIS AG (CH) | 2019-10-16 | — | — | EP | disclosed |
| US-10029994-B2 | Isoxazole hydroxamic acid compounds as LpxC inhibitors | NOVARTIS AG (CH) | 2018-07-24 | — | — | US | disclosed |
| US-20180030004-A1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LpxC INHIBITORS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2018-02-01 | — | — | US | disclosed |
| US-9815804-B2 | Isoxazole hydroxamic acid compounds as LpxC inhibitors | NOVARTIS AG (CH) | 2017-11-14 | — | — | US | disclosed |
| EP-3233843-A1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LPXC INHIBITORS | Novartis AG (CH) | 2017-10-25 | — | — | EP | disclosed |
| US-20170088525-A1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LpxC INHIBITORS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2017-03-30 | — | — | US | disclosed |
| US-9549916-B2 | Isoxazole hydroxamic acid compounds as LpxC inhibitors | NOVARTIS AG (CH) | 2017-01-24 | — | — | US | disclosed |
| WO-2016097995-A1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LPXC INHIBITORS | NOVARTIS AG (CH) | 2016-06-23 | — | — | WO | disclosed |
| US-20160166548-A1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LpxC INHIBITORS | NOVARTIS AG (CH) | 2016-06-16 | — | — | US | disclosed |