⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23851348 | 1.00 | — | — | |
| SCHEMBL13245181 | 0.82 | — | — | |
| SCHEMBL14737674 | 0.80 | — | — | |
| SCHEMBL14737673 | 0.80 | — | — | |
| SCHEMBL18042506 | 0.77 | PPM1D (0.33) | — | |
| SCHEMBL18042534 | 0.77 | PPM1D (0.33) | — | |
| SCHEMBL1795645 | 0.77 | PPM1D (0.33) | — | |
| SCHEMBL4333519 | 0.75 | PPM1D (0.33) | — | |
| SCHEMBL2944859 | 0.75 | PPM1D (0.33) | — | |
| SCHEMBL31390568 | 0.75 | PPM1D (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260092055-A1 | Aromatic Acetylene Derivative, Preparation Method Therefor, And Pharmaceutical Use Thereof | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2026-04-02 | — | — | US | disclosed |
| CN-120035588-A | Aromatic acetylene derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2025-05-23 | — | — | CN | disclosed |
| CN-119923396-A | Aromatic acetylene derivative, preparation method and medical application thereof | 浙江海正药业股份有限公司 | 2025-05-02 | — | — | CN | disclosed |
| WO-2025026955-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS | GALAPAGOS NV (BE) | 2025-02-06 | — | — | WO | disclosed |
| WO-2024129763-A1 | MODULATORS OF TNF-α ACTIVITY | FORWARD THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | WO | disclosed |
| WO-2024083177-A1 | AROMATIC ACETYLENE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 浙江海正药业股份有限公司 | 2024-04-25 | — | — | WO | disclosed |
| WO-2024067813-A1 | AROMATIC ACETYLENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 浙江海正药业股份有限公司 | 2024-04-04 | — | — | WO | disclosed |
| EP-3233843-B1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LPXC INHIBITORS | NOVARTIS AG (CH) | 2019-10-16 | — | — | EP | disclosed |
| US-9815804-B2 | Isoxazole hydroxamic acid compounds as LpxC inhibitors | NOVARTIS AG (CH) | 2017-11-14 | — | — | US | disclosed |
| EP-3233843-A1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LPXC INHIBITORS | Novartis AG (CH) | 2017-10-25 | — | — | EP | disclosed |
| US-20170088525-A1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LpxC INHIBITORS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2017-03-30 | — | — | US | disclosed |
| US-9549916-B2 | Isoxazole hydroxamic acid compounds as LpxC inhibitors | NOVARTIS AG (CH) | 2017-01-24 | — | — | US | disclosed |
| WO-2016097995-A1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LPXC INHIBITORS | NOVARTIS AG (CH) | 2016-06-23 | — | — | WO | disclosed |
| US-20160166548-A1 | ISOXAZOLE HYDROXAMIC ACID COMPOUNDS AS LpxC INHIBITORS | NOVARTIS AG (CH) | 2016-06-16 | — | — | US | disclosed |