Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 4/20 | 0.55 |
| ▸ | GSK3A | P49840 | 6/20 | 0.49 |
| ▸ | GSK3B | P49841 | 6/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.49 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264861 | 0.97 | EIF2AK4 (0.55) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16246066 | 0.94 | EIF2AK4 (0.51) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16245534 | 0.94 | GSK3A (0.57) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL17821175 | 0.92 | EIF2AK4 (0.56) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL17821182 | 0.91 | GSK3A (0.51) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16245585 | 0.91 | EIF2AK4 (0.47) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16245626 | 0.89 | GSK3A (0.59) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16245609 | 0.88 | JAK2 (0.42) | EIF2AK4ITKJAK2HDAC6HDAC1 | |
| SCHEMBL16245915 | 0.88 | GSK3A (0.52) | EIF2AK4GSK3AGSK3BAURKAMAPK6 | |
| SCHEMBL16246069 | 0.88 | EIF2AK4 (0.51) | EIF2AK4GSK3AGSK3BAURKAMAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9861635-B2 | Macrocycles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| US-9861635-B2 | Macrocycles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| EP-2994471-B1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | EIF2AK4, CDK2, CDK1 | EIF2AK4 1/4885GSK3A 523/4885GSK3B 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.