Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 8/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13819109 | 0.80 | PARG (0.54) | PARGPIK3CGTAS2R14PKMHTT | |
| SCHEMBL19785655 | 0.78 | PARG (0.48) | PARGPIK3CGTAS2R14PKMHTT | |
| SCHEMBL29992536 | 0.77 | PARG (0.41) | PARGLMNAKDM4ERXFP1 | |
| SCHEMBL17824893 | 0.76 | PARG (1.00) | PARG | |
| SCHEMBL17832062 | 0.72 | PIK3CG (0.72) | PARGPIK3CGTAS2R14PKMHTT | |
| SCHEMBL17825042 | 0.67 | ATM (0.56) | PARGPIK3CGPKMHTTLMNA | |
| SCHEMBL31122052 | 0.66 | PARG (0.68) | PARG | |
| SCHEMBL17845231 | 0.66 | PARG (0.68) | PARG | |
| SCHEMBL6799654 | 0.66 | FEN1 (0.54) | PARGPIK3CGPKMHTTLMNA | |
| SCHEMBL29835175 | 0.64 | SLC1A3 (0.37) | PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230273-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | Cancer Research Technology Ltd (GB) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |