Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 20/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17825051 | 0.85 | PARG (0.72) | PARG | |
| SCHEMBL17824786 | 0.83 | PARG (1.00) | PARG | |
| SCHEMBL17825032 | 0.79 | PARG (0.76) | PARG | |
| SCHEMBL17825161 | 0.76 | PARG (0.73) | PARG | |
| SCHEMBL17825140 | 0.75 | PARG (1.00) | PARG | |
| SCHEMBL17824704 | 0.74 | PARG (1.00) | PARG | |
| SCHEMBL17825111 | 0.73 | PARG (0.80) | PARG | |
| SCHEMBL17825285 | 0.73 | PARG (0.42) | PARG | |
| SCHEMBL17825175 | 0.73 | PARG (1.00) | PARG | |
| SCHEMBL17824885 | 0.72 | PARG (1.00) | PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230273-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | Cancer Research Technology Ltd (GB) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |