Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29459708 | 1.00 | PARG (1.00) | PARG | |
| SCHEMBL17824828 | 0.91 | PARG (1.00) | PARG | |
| SCHEMBL17824685 | 0.87 | PARG (1.00) | PARG | |
| SCHEMBL17825352 | 0.86 | PARG (1.00) | PARG | |
| SCHEMBL19770727 | 0.86 | PARG (1.00) | PARG | |
| SCHEMBL17824833 | 0.86 | PARG (1.00) | PARG | |
| SCHEMBL24570171 | 0.85 | PARG (0.74) | PARG | |
| SCHEMBL31072665 | 0.85 | PARG (1.00) | PARG | |
| SCHEMBL19770734 | 0.85 | PARG (1.00) | PARG | |
| SCHEMBL17824866 | 0.84 | PARG (1.00) | PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230273-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | Cancer Research Technology Ltd (GB) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016092326-A1 | 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2016-06-16 | — | — | WO | disclosed |