Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17968898 | 0.87 | HTT (0.57) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL28978045 | 0.82 | HTT (0.68) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL2857988 | 0.81 | HTT (0.62) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7281136 | 0.81 | HTT (0.65) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4111032 | 0.81 | HTT (0.62) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL23706353 | 0.80 | SMN1; SMN2 (0.68) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL2527774 | 0.80 | HTT (0.67) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL3693457 | 0.79 | HTT (0.73) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7134625 | 0.78 | SMN1; SMN2 (0.60) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL4111065 | 0.78 | HTT (0.65) | HTTSMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230276-A1 | GLP-1 RECEPTOR MODULATORS | Celgene International II Sarl (CH) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |