Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | PLA2G4B | P0C869 | 5/20 | 0.66 |
| ▸ | PLK1 | P53350 | 4/20 | 0.63 |
| ▸ | RARB | P10826 | 3/20 | 0.62 |
| ▸ | PPARG | P37231 | 2/20 | 0.62 |
| ▸ | PPARA | Q07869 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11609121 | 0.94 | TP53 (0.71) | TP53TSHRPLA2G4BPLK1RARB | |
| SCHEMBL9999802 | 0.91 | PLK1 (0.66) | TP53TSHRPLA2G4BPLK1RARB | |
| SCHEMBL6539579 | 0.87 | MAPT (0.64) | TP53TSHRPLA2G4BPLK1RARB | |
| SCHEMBL7337735 | 0.87 | MAPT (0.64) | TP53TSHRPLA2G4BPLK1RARB | |
| SCHEMBL7339228 | 0.87 | MAPT (0.64) | TP53TSHRPLA2G4BPLK1RARB | |
| SCHEMBL28587470 | 0.86 | TP53 (0.64) | TP53TSHRPLA2G4BPLK1PPARG | |
| SCHEMBL17825336 | 0.86 | TP53 (0.64) | TP53TSHRPLA2G4BPLK1RARB | |
| SCHEMBL10421519 | 0.86 | TP53 (0.60) | TP53TSHRPLA2G4BPLK1RARB | |
| SCHEMBL8742513 | 0.86 | ALPI (0.70) | TP53TSHRPLA2G4BPLK1PPARG | |
| SCHEMBL7338963 | 0.85 | MAPT (0.66) | TP53TSHRPLA2G4BPLK1RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230276-A1 | GLP-1 RECEPTOR MODULATORS | Celgene International II Sarl (CH) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016094729-A1 | GLP-1 RECEPTOR MODULATORS | CELGENE INTERNATIONAL II SARL (CH) | 2016-06-16 | — | — | WO | disclosed |