Known targets — ChEMBL curated mechanism
CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8
The experimentally established mechanism targets of Pregabalin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 known ✓ | P54289 | 2/20 | 0.96 |
| ▸ | CACNB3 known ✓ | P54284 | 1/20 | 0.96 |
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.96 |
| ▸ | CACNA2D2 known ✓ | Q9NY47 | 1/20 | 0.96 |
| ▸ | PGR | P06401 | 1/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.96 |
| ▸ | HTR2B | P41595 | 1/20 | 0.96 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 4/20 | 0.38 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pregabalin SCHEMBL1561104 | 0.98 | CACNA2D1 (1.00) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Pregabalin SCHEMBL263450 | 0.98 | CACNA2D1 (1.00) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Pregabalin SCHEMBL8227 | 0.98 | CACNA2D1 (1.00) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Pregabalin SCHEMBL27754092 | 0.98 | CACNA2D1 (1.00) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Pregabalin SCHEMBL2370227 | 0.98 | CACNA2D1 (1.00) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Pregabalin SCHEMBL15497 | 0.98 | CACNA2D1 (1.00) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Pregabalin SCHEMBL2966808 | 0.96 | CACNA2D1 (0.96) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Pregabalin SCHEMBL4608711 | 0.96 | CACNA2D1 (0.96) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Pregabalin SCHEMBL19031786 | 0.96 | CACNA2D1 (0.96) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Pregabalin SCHEMBL3371102 | 0.96 | CACNA2D1 (0.96) | CACNA2D1CACNB3CACNA1CPGRADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200222544-A1 | LINEAR POLYSACCHARIDE BASED FILM PRODUCTS | AQUESTIVE THERAPEUTICS, INC. | 2020-07-16 | — | — | US | disclosed |
| US-20180280518-A1 | LINEAR POLYSACCHARIDE BASED FILM PRODUCTS | AQUESTIVE THERAPEUTICS, INC. | 2018-10-04 | — | — | US | disclosed |
| US-20170360942-A1 | LINEAR POLYSACCHARIDE BASED FILM PRODUCTS | MONOSOL RX, INC. | 2017-12-21 | — | — | US | disclosed |
| EP-3229778-A1 | LINEAR POLYSACCHARIDE BASED FILM PRODUCTS | MonoSol Rx LLC (US) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016094567-A1 | LINEAR POLYSACCHARIDE BASED FILM PRODUCTS | MONOSOL RX, LLC (US) | 2016-06-16 | — | — | WO | disclosed |