Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 18/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16070072 | 0.87 | ATR (0.78) | ATR | |
| SCHEMBL16420638 | 0.87 | ATR (0.58) | ATRCHEK2MET | |
| SCHEMBL16420590 | 0.78 | ATR (0.75) | ATR | |
| SCHEMBL16420480 | 0.77 | ATR (0.77) | ATR | |
| SCHEMBL16420517 | 0.76 | ATR (0.50) | ATR | |
| SCHEMBL13138250 | 0.74 | ATR (0.77) | ATRCHEK2MET | |
| SCHEMBL16420702 | 0.73 | ATR (0.59) | ATR | |
| SCHEMBL16420714 | 0.73 | ATR (0.73) | ATR | |
| SCHEMBL16420521 | 0.72 | ATR (0.47) | ATR | |
| SCHEMBL16420537 | 0.72 | ATR (0.75) | ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160311809-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-10-27 | — | — | US | disclosed |
| US-9365557-B2 | Substituted pyrazin-2-amines as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160311809-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K5 | ATR 1/4885CHEK2 5/4885MET 2931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.