Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.66 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.48 |
| ▸ | CDK2 | P24941 | 7/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 7/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13845587 | 0.82 | CHEK1 (0.72) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14231851 | 0.80 | CHEK1 (0.72) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930916 | 0.80 | CHEK1 (0.98) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930914 | 0.79 | CHEK1 (1.00) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14232212 | 0.76 | CHEK1 (0.74) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930918 | 0.76 | CHEK1 (1.00) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL16784490 | 0.71 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543213 | 0.71 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL15146171 | 0.69 | CHEK1 (0.59) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930920 | 0.69 | CHEK1 (0.82) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069349-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-06-15 | — | — | EP | disclosed |