Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 10/20 | 0.38 |
| ▸ | JAK2 | O60674 | 8/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536810 | 0.87 | JAK3 (0.46) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL13579878 | 0.87 | JAK3 (0.46) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL1536809 | 0.87 | JAK3 (0.46) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL1536881 | 0.86 | JAK3 (0.44) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL1536883 | 0.86 | JAK3 (0.44) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL13579882 | 0.86 | JAK3 (0.44) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL13579883 | 0.84 | JAK3 (0.43) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL1536865 | 0.84 | JAK3 (0.43) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL1536864 | 0.84 | JAK3 (0.43) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL13579884 | 0.83 | JAK3 (0.41) | JAK3AURKATYK2JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3031324-A2 | TRICYCLIC KINASE INHIBITORS | AbbVie Inc. (US) | 2016-06-15 | — | — | EP | disclosed |