Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 12/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 10/20 | 0.40 |
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | PRKCA | P17252 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13580608 | 0.75 | CSF1R (0.38) | JAK3TYK2JAK1JAK2 | |
| SCHEMBL19292158 | 0.72 | IKBKB (0.46) | JAK3TYK2JAK1JAK2 | |
| SCHEMBL14493881 | 0.70 | JAK3 (0.56) | JAK3HPGDSAURKATYK2JAK1 | |
| SCHEMBL1934804 | 0.69 | JAK2 (0.60) | JAK3HPGDSAURKATYK2JAK1 | |
| SCHEMBL1536982 | 0.69 | JAK3 (0.59) | JAK3AURKATYK2JAK1JAK2 | |
| SCHEMBL14493884 | 0.69 | JAK3 (0.59) | JAK3HPGDSAURKATYK2JAK1 | |
| SCHEMBL1536810 | 0.69 | JAK3 (0.46) | JAK3HPGDSAURKATYK2JAK1 | |
| SCHEMBL1536809 | 0.69 | JAK3 (0.46) | JAK3HPGDSAURKATYK2JAK1 | |
| SCHEMBL13579878 | 0.69 | JAK3 (0.46) | JAK3HPGDSAURKATYK2JAK1 | |
| SCHEMBL15372867 | 0.69 | TTBK1 (0.43) | JAK3TYK2JAK1JAK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3031324-A2 | TRICYCLIC KINASE INHIBITORS | AbbVie Inc. (US) | 2016-06-15 | — | — | EP | disclosed |