SCHEMBL17827182

SCHEMBL17827182

CC(C)(C)[Si](C)(C)OCc1nc(-c2c(C#N)c(N)nc(SCc3csc(-c4ccc(Cl)cc4)n3)c2C#N)cs1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 20/20 0.66
SLC6A3 Q01959 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2288735 0.87 ADORA1 (0.62) ADORA1SLC6A3
SCHEMBL381608 0.85 ADORA1 (0.77) ADORA1SLC6A3
SCHEMBL1076833 0.83 ADORA1 (0.75) ADORA1SLC6A3
SCHEMBL1072685 0.82 ADORA1 (0.70) ADORA1SLC6A3
SCHEMBL924122 0.81 ADORA1 (0.68) ADORA1SLC6A3
SCHEMBL924121 0.81 ADORA1 (0.68) ADORA1SLC6A3
SCHEMBL12376510 0.80 ADORA1 (0.53) ADORA1SLC6A3
SCHEMBL12910839 0.80 ADORA1 (0.65) ADORA1SLC6A3
SCHEMBL2282177 0.79 ADORA1 (0.73) ADORA1SLC6A3
SCHEMBL3583162 0.79 ADORA1 (0.59) ADORA1SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2274299-B1 HETEROARYL-SUBSTITUTED DICYANOPYRIDINES AND USE THEREOF FOR TREATMENT OF CARDIOVASCULAR DISEASES BAYER IP GMBH (DE) 2016-06-15 EP disclosed