Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 20/20 | 0.82 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16218321 | 0.90 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL15071077 | 0.90 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL15071020 | 0.79 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL15060342 | 0.76 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL16218320 | 0.76 | PDE4D (0.86) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3469495 | 0.76 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL508401 | 0.71 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL16435086 | 0.71 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL508408 | 0.71 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL508927 | 0.71 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794603-B1 | [1,2,4]TRIAZOLOPYRIDINES AND THEIR USE AS PHOSPODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-06-15 | — | — | EP | disclosed |