Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 6/20 | 0.58 |
| ▸ | GSK3B | P49841 | 6/20 | 0.58 |
| ▸ | AURKA | O14965 | 4/20 | 0.58 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 10/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16245880 | 0.99 | GSK3A (0.57) | GSK3AGSK3BAURKAEIF2AK4JAK2 | |
| SCHEMBL16264890 | 0.88 | EIF2AK4 (0.60) | GSK3AGSK3BAURKAEIF2AK4JAK2 | |
| SCHEMBL18869417 | 0.88 | GSK3A (0.51) | GSK3AGSK3BAURKAEIF2AK4JAK2 | |
| Hydrochloric Acid SCHEMBL16246073 | 0.87 | GSK3A (0.50) | GSK3AGSK3BAURKAEIF2AK4JAK2 | |
| SCHEMBL16245882 | 0.87 | EIF2AK4 (0.60) | GSK3AGSK3BAURKAEIF2AK4JAK2 | |
| Hydrochloric Acid SCHEMBL17821173 | 0.86 | EIF2AK4 (0.59) | GSK3AGSK3BAURKAEIF2AK4JAK2 | |
| SCHEMBL16245597 | 0.85 | EIF2AK4 (0.60) | GSK3AGSK3BAURKAEIF2AK4JAK2 | |
| SCHEMBL16246069 | 0.84 | EIF2AK4 (0.51) | GSK3AGSK3BAURKAEIF2AK4JAK2 | |
| Hydrochloric Acid SCHEMBL17821184 | 0.84 | EIF2AK4 (0.59) | GSK3AGSK3BAURKAEIF2AK4JAK2 | |
| SCHEMBL17821181 | 0.84 | GSK3A (0.66) | GSK3AGSK3BAURKAEIF2AK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9861635-B2 | Macrocycles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | EIF2AK4, CDK2, CDK1 | GSK3A 523/4885GSK3B 482/4885AURKA 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.