Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20271067 | 0.89 | CTNNB1 (0.37) | DYRK1APRKCISMN1; SMN2DYRK1BCLK1 | |
| SCHEMBL13114355 | 0.80 | DYRK1A (0.38) | DYRK1APRKCIMAPTRAB9ANPC1 | |
| SCHEMBL18443076 | 0.77 | MAPT (0.41) | MAPTRAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL20073453 | 0.76 | DYRK1A (0.38) | DYRK1APRKCIHDAC3HDAC4HDAC1 | |
| SCHEMBL21371861 | 0.76 | DYRK1A (0.38) | DYRK1APRKCIHDAC3HDAC4HDAC1 | |
| SCHEMBL17828247 | 0.76 | DYRK1A (0.49) | DYRK1APRKCIHDAC3HDAC4HDAC1 | |
| SCHEMBL23349388 | 0.72 | MAPT (0.39) | DYRK1APRKCIHDAC3HDAC4HDAC1 | |
| SCHEMBL2939393 | 0.72 | PRKCI (0.38) | DYRK1APRKCIHDAC3HDAC4HDAC1 | |
| SCHEMBL12526762 | 0.72 | OGA (0.37) | DYRK1APRKCIHDAC3HDAC4HDAC1 | |
| SCHEMBL30718843 | 0.72 | ERN1 (0.41) | DYRK1APRKCIHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975910-B2 | Hetero-fused cyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-05-22 | — | — | US | disclosed |
| US-9975910-B2 | Hetero-fused cyclic compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-05-22 | — | — | US | disclosed |
| US-20160168176-A1 | HETERO-FUSED CYCLIC COMPOUND | Eisai R&D Management Co., Lt.d (JP) | 2016-06-16 | — | — | US | disclosed |
| US-20160168176-A1 | HETERO-FUSED CYCLIC COMPOUND | Eisai R&D Management Co., Lt.d (JP) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168176-A1 | HETERO-FUSED CYCLIC COMPOUND | NR3C2, NR1H4, NR1I3 | DYRK1A 3435/4885PRKCI 4322/4885HDAC3 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.