⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829246 | 0.92 | — | — | |
| SCHEMBL17828670 | 0.89 | — | — | |
| SCHEMBL17829062 | 0.88 | — | — | |
| SCHEMBL17828694 | 0.86 | — | — | |
| SCHEMBL19625192 | 0.85 | — | — | |
| SCHEMBL17828673 | 0.85 | — | — | |
| SCHEMBL17828697 | 0.83 | — | — | |
| SCHEMBL17829061 | 0.82 | — | — | |
| SCHEMBL17829131 | 0.82 | — | — | |
| SCHEMBL17828696 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3229805-B1 | SPIROCYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-04-19 | — | — | EP | disclosed |
| EP-3229804-B1 | SPIROCYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME (US) | 2020-05-06 | — | — | EP | disclosed |
| US-10221186-B2 | Spirocyclic heterocyclic compounds useful as HIV integrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20170362252-A1 | Spirocyclic Heterocycle Compounds Useful as HIV Integrase Inhibitors | MERCK SHARP & DOHME LLC | 2017-12-21 | — | — | US | disclosed |
| US-20170362252-A1 | Spirocyclic Heterocycle Compounds Useful as HIV Integrase Inhibitors | MERCK SHARP & DOHME LLC | 2017-12-21 | — | — | US | disclosed |
| US-20170334924-A1 | Spirocyclic Heterocyclic Compounds Useful As HIV Integrase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-23 | — | — | US | disclosed |
| US-20170334924-A1 | Spirocyclic Heterocyclic Compounds Useful As HIV Integrase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-11-23 | — | — | US | disclosed |
| WO-2016094198-A1 | SPIROCYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-16 | — | — | WO | disclosed |
| WO-2016094197-A1 | SPIROCYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-16 | — | — | WO | disclosed |