Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.65 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.65 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.65 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.56 |
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | IGF1R | P08069 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17553703 | 0.89 | CCNB2 (0.69) | FLT3MKNK1MKNK2CCNB2CDK1 | |
| SCHEMBL29973816 | 0.85 | FLT3 (0.65) | FLT3MKNK1MKNK2CCNB2CDK1 | |
| SCHEMBL14663441 | 0.85 | FLT3 (0.65) | FLT3MKNK1MKNK2CCNB2CDK1 | |
| SCHEMBL28378828 | 0.81 | MKNK1 (0.66) | FLT3MKNK1MKNK2EGFRKCNH2 | |
| SCHEMBL4513070 | 0.81 | ABL1 (0.64) | FLT3MKNK1MKNK2CCNB2CDK1 | |
| SCHEMBL30378140 | 0.80 | EGFR (0.71) | FLT3MKNK1MKNK2EGFRKCNH2 | |
| SCHEMBL30120921 | 0.80 | EGFR (0.71) | FLT3MKNK1MKNK2EGFRKCNH2 | |
| SCHEMBL14663465 | 0.80 | EGFR (0.71) | FLT3MKNK1MKNK2EGFRKCNH2 | |
| SCHEMBL17831509 | 0.80 | EGFR (0.61) | FLT3MKNK1MKNK2CCNB2CDK1 | |
| SCHEMBL17831600 | 0.80 | MKNK1 (0.74) | FLT3MKNK1MKNK2CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362203-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINE DERIVATIVES AS EGFR MODULATORS | BETA PHARMA, INC. (US) | 2017-12-21 | — | — | US | disclosed |
| US-20170362203-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINE DERIVATIVES AS EGFR MODULATORS | BETA PHARMA, INC. (US) | 2017-12-21 | — | — | US | disclosed |
| WO-2016094821-A2 | SUBSTITUTED 2-ANILINOPYRIMIDINE DERIVATIVES AS EGFR MODULATORS | BETA PHARMA, INC. (US) | 2016-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362203-A1 | SUBSTITUTED 2-ANILINOPYRIMIDINE DERIVATIVES AS EGFR MODULATORS | EGFR, ERBB2, ERBB4 | FLT3 25/4885MKNK1 1174/4885MKNK2 1100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.