Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829964 | 0.91 | CYP1A2 (0.37) | SYKCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL17829881 | 0.90 | RAD52 (0.47) | ALDH1A1MAPK1RAD52KMT2A | |
| SCHEMBL17829952 | 0.88 | SYK (0.49) | SYKCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL17829946 | 0.84 | SYK (0.47) | SYKALDH1A1ROCK2ROCK1KDM4E | |
| SCHEMBL17833268 | 0.84 | SYK (0.56) | SYKALDH1A1ROCK2ROCK1IRAK4 | |
| SCHEMBL17829578 | 0.82 | RAD52 (0.47) | ALDH1A1MAPK1RAD52KMT2A | |
| SCHEMBL17833150 | 0.81 | CYP1A2 (0.41) | CYP1A2CYP3A4CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL17829956 | 0.80 | SYK (0.47) | SYKALDH1A1ROCK2ROCK1IRAK4 | |
| SCHEMBL17829874 | 0.80 | RAD52 (0.47) | CYP1A2CYP3A4CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL17833283 | 0.79 | SYK (0.40) | SYKCYP1A2CYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016094730-A1 | HETEROCYCLIC COMPOUNDS AS ANTIBIOTIC POTENTIATORS | SYNERECA PHARMACEUTICALS, INC. (US) | 2016-06-16 | — | — | WO | disclosed |