Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 5/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220706 | 0.98 | CYP2C19 (0.54) | CYP2C19TBXAS1LMNASLC22A6TSHR | |
| SCHEMBL250972 | 0.96 | CYP2C19 (0.57) | CYP2C19TBXAS1LMNASLC22A6TSHR | |
| SCHEMBL277893 | 0.96 | CYP2C19 (0.57) | CYP2C19TBXAS1LMNASLC22A6TSHR | |
| Cyclohexane SCHEMBL8602472 | 0.96 | CYP2C19 (0.57) | CYP2C19TBXAS1LMNASLC22A6TSHR | |
| SCHEMBL248718 | 0.96 | CYP2C19 (0.57) | CYP2C19TBXAS1LMNASLC22A6TSHR | |
| SCHEMBL249733 | 0.96 | CYP2C19 (0.57) | CYP2C19TBXAS1LMNASLC22A6TSHR | |
| SCHEMBL3101468 | 0.96 | CYP2C19 (0.57) | CYP2C19TBXAS1LMNASLC22A6TSHR | |
| SCHEMBL220603 | 0.96 | CYP2C19 (0.57) | CYP2C19TBXAS1LMNASLC22A6TSHR | |
| SCHEMBL249881 | 0.96 | CYP2C19 (0.57) | CYP2C19TBXAS1LMNASLC22A6TSHR | |
| SCHEMBL250046 | 0.96 | CYP2C19 (0.57) | CYP2C19TBXAS1LMNASLC22A6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844685-B1 | COPOLYMERS BASED ON REACTIVE POLYESTERS AND PLASTICISERS FOR THE MANUFACTURE OF TRANSPARENT, BIODEGRADABLE PACKAGING FILM | UNIV PISA (IT) | 2016-06-22 | — | — | EP | claimed |