Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.69 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.69 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.69 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.69 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842736 | 0.95 | MTOR (0.71) | MTORKCNH2RICTORRPTORMAPKAP1 | |
| SCHEMBL14852657 | 0.93 | MTOR (0.80) | MTORKCNH2RICTORRPTORMAPKAP1 | |
| SCHEMBL17836777 | 0.91 | MTOR (0.72) | MTORKCNH2RICTORRPTORMAPKAP1 | |
| SCHEMBL14842915 | 0.89 | MTOR (0.87) | MTORKCNH2RICTORRPTORMAPKAP1 | |
| SCHEMBL14842918 | 0.89 | MTOR (0.87) | MTORKCNH2RICTORRPTORMAPKAP1 | |
| SCHEMBL14843084 | 0.89 | MTOR (0.81) | MTORKCNH2RICTORRPTORMAPKAP1 | |
| SCHEMBL14842734 | 0.89 | MTOR (0.81) | MTORKCNH2RICTORRPTORMAPKAP1 | |
| SCHEMBL14843085 | 0.88 | MTOR (0.66) | MTORKCNH2RICTORRPTORMAPKAP1 | |
| SCHEMBL17836785 | 0.88 | MTOR (0.66) | MTORKCNH2RICTORRPTORMAPKAP1 | |
| SCHEMBL17836791 | 0.88 | MTOR (0.76) | MTORKCNH2RICTORRPTORMAPKAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763985-B1 | {(4-(4-MORPHOLINO-DIHYDROTHIENO[3,4-D]PYRIMIDIN-2-YL)ARYL}UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LTD (GB) | 2016-06-22 | — | — | EP | claimed |