Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.62 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.56 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.56 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842780 | 0.92 | MTOR (0.64) | MTORPIK3CARPTORMLST8KCNH2 | |
| SCHEMBL14842721 | 0.90 | MTOR (0.69) | MTORPIK3CARPTORMLST8KCNH2 | |
| SCHEMBL17836779 | 0.90 | MTOR (0.69) | MTORPIK3CARPTORMLST8KCNH2 | |
| SCHEMBL17836768 | 0.90 | MTOR (0.69) | MTORPIK3CARPTORMLST8KCNH2 | |
| SCHEMBL14842891 | 0.88 | MTOR (0.79) | MTORPIK3CARPTORMLST8KCNH2 | |
| SCHEMBL14842718 | 0.88 | MTOR (0.79) | MTORPIK3CARPTORMLST8KCNH2 | |
| SCHEMBL17836770 | 0.87 | MTOR (0.70) | MTORPIK3CARPTORMLST8KCNH2 | |
| SCHEMBL17836793 | 0.87 | MTOR (0.60) | MTORPIK3CARPTORMLST8KCNH2 | |
| SCHEMBL14843548 | 0.87 | MTOR (0.60) | MTORPIK3CARPTORMLST8KCNH2 | |
| SCHEMBL443558 | 0.86 | MTOR (0.63) | MTORPIK3CARPTORMLST8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763985-B1 | {(4-(4-MORPHOLINO-DIHYDROTHIENO[3,4-D]PYRIMIDIN-2-YL)ARYL}UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LTD (GB) | 2016-06-22 | — | — | EP | claimed |