Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MGMT | P16455 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31395761 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT | |
| SCHEMBL13554631 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT | |
| SCHEMBL16437097 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT | |
| SCHEMBL13498593 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT | |
| SCHEMBL16899909 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT | |
| SCHEMBL14763470 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT | |
| SCHEMBL18576097 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT | |
| SCHEMBL13449860 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT | |
| SCHEMBL16899883 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT | |
| SCHEMBL31577560 | 1.00 | MEN1 (0.52) | MEN1KMT2ATSHRMAPK1MGMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190352625-A1 | MUTANTS OF COCAINE ESTERASE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-11-21 | — | — | US | claimed |
| US-10160960-B2 | Mutants of cocaine esterase | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-12-25 | — | — | US | claimed |
| US-20160177277-A1 | MUTANTS OF COCAINE ESTERASE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-06-23 | — | — | US | claimed |
| WO-2025031923-A1 | IMIDAZO[4,5-D]PYRIDAZINE COMPOUNDS AND CONJUGATES THEREOF, THEIR PREPARATION, AND THEIR THERAPEUTIC APPLICATIONS | SANOFI (FR) | 2025-02-13 | — | — | WO | disclosed |
| US-11289238-B2 | Compositions for the filling of high aspect ratio vertical interconnect access (VIA) holes | HERAEUS PRECIOUS METALS NORTH AMERICA CONSHOHOCKEN LLC (US) | 2022-03-29 | — | — | US | disclosed |
| US-20210174983-A1 | COMPOSITIONS FOR THE FILLING OF HIGH ASPECT RATIO VERTICAL INTERCONNECT ACCESS (VIA) HOLES | HERAEUS PRECIOUS METALS NORTH AMERICA CONSHOHOCKEN LLC | 2021-06-10 | — | — | US | disclosed |
| US-20190352625-A1 | MUTANTS OF COCAINE ESTERASE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-11-21 | — | — | US | disclosed |
| US-10160960-B2 | Mutants of cocaine esterase | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-12-25 | — | — | US | disclosed |
| US-20160177277-A1 | MUTANTS OF COCAINE ESTERASE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-06-23 | — | — | US | disclosed |