Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 9/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.56 |
| ▸ | BRAF | P15056 | 3/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.54 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.54 |
| ▸ | NEK2 | P51955 | 2/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.54 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.54 |
| ▸ | NEK11 | Q8NG66 | 2/20 | 0.54 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.54 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.54 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL294079 | 0.91 | CYP2C9 (0.68) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF | |
| SCHEMBL294876 | 0.86 | CYP2C9 (0.80) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF | |
| SCHEMBL299456 | 0.85 | CYP2D6 (0.61) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF | |
| SCHEMBL7868921 | 0.84 | BRAF (0.69) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF | |
| SCHEMBL295823 | 0.84 | CYP2C9 (0.61) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF | |
| SCHEMBL299073 | 0.83 | CYP2C9 (0.66) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF | |
| SCHEMBL417233 | 0.83 | CYP3A4 (0.80) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF | |
| SCHEMBL12703264 | 0.83 | CYP3A4 (0.67) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF | |
| SCHEMBL12703147 | 0.82 | CYP3A4 (0.73) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF | |
| SCHEMBL298479 | 0.82 | BRAF (0.79) | CYP2C9CYP2C19CYP2D6CYP3A4BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160176865-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176865-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | CYP2C9 4746/4885CYP2C19 4579/4885CYP2D6 4480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.