Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 20/20 | 0.82 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860942 | 0.90 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL25345197 | 0.87 | TLR8 (0.73) | TLR8TLR7 | |
| SCHEMBL25342503 | 0.85 | TLR8 (0.71) | TLR8TLR7 | |
| SCHEMBL17861095 | 0.85 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL31541723 | 0.84 | TLR8 (0.65) | TLR8TLR7 | |
| SCHEMBL25344755 | 0.84 | TLR8 (0.65) | TLR8TLR7 | |
| SCHEMBL17861036 | 0.83 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL25684248 | 0.83 | TLR8 (0.86) | TLR8TLR7 | |
| SCHEMBL20492771 | 0.82 | TLR8 (0.71) | TLR8TLR7 | |
| SCHEMBL25344657 | 0.80 | TLR8 (0.63) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233835-B1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2019-01-23 | — | — | EP | disclosed |
| US-9890124-B2 | Benzazepine sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| EP-3233835-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2017-10-25 | — | — | EP | disclosed |
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-09-28 | — | — | US | disclosed |
| WO-2016096778-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | TLR8, TLR7, TLR5 | TLR8 1/4885TLR7 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.