SCHEMBL17843641

SCHEMBL17843641

COc1ccc(-c2cc3cc(OCCF)cc(Br)c3oc2=O)cc1

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 11/20 0.67
ADORA3 P0DMS8 2/20 0.52
NPC1 O15118 3/20 0.51
RAB9A P51151 3/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
MAOA P21397 1/20 0.46
RXFP1 Q9HBX9 3/20 0.46
MIF P14174 1/20 0.46
SIRT3 Q9NTG7 1/20 0.46
ERAP1 Q9NZ08 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46
MAPT P10636 1/20 0.44
GPR35 Q9HC97 1/20 0.44
ACHE P22303 1/20 0.43
TP53 P04637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17843631 0.91 MAOB (0.56) MAOBADORA3NPC1RAB9AMEN1
SCHEMBL11297367 0.82 MAOB (0.79) MAOBADORA3NPC1RAB9AMEN1
SCHEMBL17857193 0.81 MAOB (1.00) MAOBADORA3NPC1RAB9AMEN1
SCHEMBL17843639 0.81 MAOB (0.69) MAOBADORA3NPC1RAB9AMEN1
SCHEMBL17843648 0.79 MAOB (0.70) MAOBADORA3NPC1RAB9AMEN1
SCHEMBL17843629 0.75 MAOB (0.55) MAOBADORA3NPC1RAB9AMEN1
SCHEMBL17843651 0.73 MAOB (0.56) MAOBADORA3NPC1RAB9AMEN1
SCHEMBL17857082 0.72 MAOB (0.52) MAOBADORA3MAOARXFP1CA1
SCHEMBL20428272 0.69 MAOB (0.67) MAOBADORA3NPC1RAB9AMEN1
SCHEMBL17857187 0.69 MAOB (1.00) MAOBADORA3NPC1RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016097339-A1 LABELLED COUMARIN DERIVATIVES GE HEALTHCARE LIMITED (GB) 2016-06-23 WO disclosed
WO-2016097339-A1 LABELLED COUMARIN DERIVATIVES GE HEALTHCARE LIMITED (GB) 2016-06-23 WO disclosed